• View the progression pattern of TTR-FAP

  • See the impact of TTR-FAP on
    patients' lives

  • Learn about diagnosis and
    patient management

Suspecting TTR-FAP

Because it is often clinically indistinguishable from other idiopathic polyneuropathies, a crucial step to diagnosing TTR-FAP is considering it in the differential diagnosis in the first place.3-8 Patients are often evaluated for years before TTR-FAP is recognized as the underlying cause of their symptoms.8 This delay in diagnosis, where the mean time to diagnosis can be up to 4 years after onset of symptoms, is particularly unfortunate, because the life expectancy of untreated patients with TTR-FAP averages only 10 years from symptom onset.3

Consider TTR-FAP in the differential diagnosis

The main clinical feature of TTR-FAP is a progressive, distal-to-proximal,
length-dependent, axonal sensorimotor neuropathy.8

Consider TTR-FAP when patients present with polyneuropathy characterized by sensory loss, pain, weakness in the lower limbs, and one or more of the following:

  • Orthostatic hypotension
  • Urogenital symptoms, such as erectile dysfunction
  • Alternating constipation and diarrhea
  • Unintentional weight loss9

When you see polyneuropathy with autonomic symptoms, this checklist can help you determine if TTR-FAP should be considered in your differential diagnosis.

Download the symptom checklist

A need for early diagnosis

Because TTR-FAP is an irreversible, progressive disease, early diagnosis is important in patient management.12,16,20