• View the progression pattern of TTR-FAP

  • Find out when to consider TTR-FAP and
    download the symptom checklist

  • Learn about diagnosis and
    patient management

TTR-FAP: A rare disease that causes neurodegeneration1,2

Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare, progressive, irreversible, and fatal neurodegenerative disease primarily caused by a genetic
mutation of TTR.1,2

In TTR-FAP, mutations in TTR lead to the formation of amyloid fibrils that deposit in peripheral and autonomic nerve tissues, resulting in neurodegeneration and decline
of neurologic function.5,10 As the disease progresses, TTR-FAP eventually
becomes fatal.11,12