• Learn more about a transthyretin
    amyloidosis patient registry

  • Access downloadable
    TTR-FAP resources

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An approach to diagnosing TTR-FAP

Once suspected, the diagnosis of TTR-FAP can be confirmed by:


  • A biopsy (nerve, subcutaneous fat aspirate, or other affected tissues) stained with Congo red to determine amyloid deposits9
    • A Congo red stain that turns apple green when viewed under
      polarized light is indicative of amyloid deposits
  • Genetic testing and protein evaluation9

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Consider options for patient management

Current therapy options for TTR-FAP are limited. Symptomatic management is primarily focused on reducing the impact of neuropathic pain and improving gastrointestinal and other autonomic symptoms.5

Orthotopic liver transplant*, which removes the primary source of abnormal TTR, may
be considered for patients with recent disease onset and no additional
organ involvement.5,21

*Liver transplantation in which the native liver is removed and the donor organ is placed in the same anatomic location as the original liver.

Learn about the impact of TTR-FAP on patients and their families

Find an Amyloid Treatment Center of Excellence